Gene Fkbp5 and Its Affect on Child Abuse and Risks of Posttraumatic Stress Disorder in Adults

RUNNING HEAD:   Association of FKBP5 and Childhood Abuse

                            Research Analysis Paper

Association of FKBP5 Polymorphisms and Childhood Abuse with

Risk of Posttraumatic Stress Disorder Symptoms in Adults

Angela Whitmore

April 13, 2008

HLTH 401

Abstract

A traumatic event such as child-abuse, witnessing a crime and/or serving time in combat all can lead to PTSD (Posttraumatic Stress Disorder).   Even though, each individual may handle the event differently PTSD can still develop as a result. Posttraumatic Stress Disorder is an anxiety disorder, which can develop after you have experienced a traumatizing event. (National Center for Posttraumatic Stress Disorder 2008). A research study was conducted to measure gene variation due to childhood abuse, resulting in PTSD. The participants included 900 African Americans 18-81 years old, from poor urban neighborhoods. Studies were based on childhood abuse and non-childhood abuse. Studies will show that a genetic variation in gene FKBP5 due to childhood abuse pose a risk and the potential for developing PTSD.

Summary

We relate PTSD to the FKBP5 gene because they both relate directly to stress levels. The gene FKBP5 produces a protein that helps regulate binding among stress hormones and their receptors on cells. When stress hormones and their receptors do not bind it could cause gene variation, this gene being FKBP5. Other terms used in this study are HPA (hypothalamic-pituitary-adrenal axis which is also called the reproductive axis. HPA is a major part of the neuro-endocrine system that controls reactions to stress and regulates various body processes, including digestion and the immune system. GR receptor (Glucocorticoid receptor), expressed in almost every cell of the body and regulates either directly or indirectly genes controlling a wide variety of processes, including the development, metabolism an immune response of the organism. DST (Dexamethasone suppression test),...
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